Skip to main content

Genetic Programming for Classifying Cancer Data and Controlling Humanoid Robots

  • Chapter
Book cover Genetic Programming Theory and Practice IV

Part of the book series: Genetic and Evolutionary Computation ((GEVO))

Abstract

In this chapter, we show the real-world applications of genetic programming (GP) to bioinformatics and robotics. In the bioinformatics application, we propose majority voting technique for the prediction of the class of a test sample. In the application to robotics, we use GP to generate the motion sequences of humanoid robots. We introduce an integrated approach, i.e., the combination of GP and reinforcement learning, to design the desirable motions. The effectiveness of our proposed approaches is demonstrated by performing experiments with real data, i.e., classifying real micro-array gene expression profiles and controlling real humanoid robots.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ando, Shin and Iba, Hitoshi (2004). Classification of gene expression profile using combinatory method of evolutionary computation and machine learning. Genetic Programming and Evolvable Machines, 5(2): 145–156.

    Article  Google Scholar 

  • Bhattacharjee, A., Richards, W.G., Stauton, J., Li, C., Monti, S., Vasa, P., Ladd, C., Behesti, J., Buneo, R., Gillete, M., Loda, M., Weber, G., Mark, E.J., Lander, E.S., Wong, W., Johnson, B.E., Golub, T.R., Sugarbaker, D.J., and Meyerson, M. (2001). Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proceedings of National Academy of Science, 98:13790–13795.

    Article  Google Scholar 

  • Driscoll, Joseph A., Worzel, Bill, and MacLean, Duncan (2003). Classification of gene expression data with genetic programming. In Riolo, Rick L. and Worzel, Bill, editors, Genetic Programming Theory and Practice, chapter 3, pages 25–42. Kluwer.

    Google Scholar 

  • Golub, T.R., Slonim, D.K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J.P., Coller, H., Loh, M.L., Downing, J.R., Caligiuri, M.A., Bloomfield, C.D., and Lander, E.S. (1999). Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science, 286(15):531–537.

    Article  Google Scholar 

  • Harbeck, N., Kates, R.E., Gauger, K., Willems, A., Kiechle, M., Magdolen, V., and Schmitt, M. (2004). Urokinase-type plasminogen activator (upa) and its inhibitor pai-i: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. Thromb Haemost., 91(3):450–456.

    Google Scholar 

  • Hedenfalk, I., Duggan, D., Chen, Y., Radmacher, M., Bittner, M., Simon, R., Meltzer, P., Gusterson, B., Esteller, M., Kallioniemi, O.P., Wilfond, B., Borg, A., and Trent, J. (2001). Gene-expression profiles in hereditary breast cancer. The New England Journal of Medicine, 344(8):539–548.

    Article  Google Scholar 

  • Hong, Jin-Hyuk and Cho, Sung Bae (2004). Lymphoma cancer classification using genetic programming with SNR features. In Keijzer, Maarten, O’Reilly, Una-May, Lucas, Simon M., Costa, Ernesto, and Soule, Terence, editors, Genetic Programming 7th European Conference, EuroGP 2004, Proceedings, volume 3003 of LNCS, pages 78–88, Coimbra, Portugal. Springer-Verlag.

    Google Scholar 

  • Iba, Hitoshi, Tohge, Takahiro, and Inoue, Yutaka (2004). Cooperative transportation by humanoid robots—solving piano movers’ problem. International Journal of Hybrid Intelligent System, 1(3–4):189–201.

    Google Scholar 

  • Inoue, Yutaka, Tohge, Takahiro, and Iba, Hitoshi (2004). Learning for cooperative transportation by autonomous humanoid robots. In Nedjah, Nadia and de Macedo Mourelle, Luiza, editors, Evolvable Machines: Theory & Practice, volume 161 of Studies in Fuzziness and Soft Computing, chapter 1, pages 3–20. Springer, Berlin.

    Google Scholar 

  • Kamio, Shotaro and Iba, Hitoshi (2005). Adaptation technique for integrating genetic programming and reinforcement learning for real robots. IEEE Transactions on Evolutionary Computation, 9(3):318–333.

    Article  Google Scholar 

  • Koza, John R. (1992). Genetic Programming: On the Programming of Computers by Means of Natural Selection. MIT Press, Cambridge, MA, USA.

    MATH  Google Scholar 

  • Kuncheva, L.I. and Whitaker, C.J. (2003). Measures of diversity in classifier ensembles and their relationships with the ensemble accuracy. Machine Learning, 51:181–207.

    Article  MATH  Google Scholar 

  • Langdon, W. B. and Buxton, B. F. (2004). Genetic programming for mining DNA chip data from cancer patients. Genetic Programming and Evolvable Machines, 5(3):251–257.

    Article  Google Scholar 

  • Matthews, B.W. (1975). Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochemica et Biophysica Acta., 405:442–451.

    Google Scholar 

  • Moore, Jason H., Parker, Joel S., Olsen, Nancy J., and Aune, Thomas M. (2002). Symbolic discriminant analysis of microarray data in automimmune disease. Genetic Epidemiology, 23:57–69.

    Article  Google Scholar 

  • Onn, Amir, Correa, Arlene M., Gilcrease, Michael, Isobe, Takeshi, Massarelli, Erminia, Bucana, Corazon D., O’Reilly, Michael S., Hong, Waun K., Fidler, Isaiah J., Putnam, Joe B., and Herbst, Roy S. (2004). Synchronous over-expression of epidermal growth factor receptor and her2-neu protein is a predictor of poor outcome in patients with stage i non-small cell lung cancer. Clinical Cancer Research, 10:136–143.

    Article  Google Scholar 

  • Paul, Topon Kumar and Iba, Hitoshi (2004a). Identification of informative genes for molecular classification using probabilistic model building genetic algorithm. In Proceedings of Genetic and Evolutionary Computation Conference 2004, number 3102 in Lecture Notes in Computer Science, LNCS, pages 414–425. Springer-Verlag.

    Google Scholar 

  • Paul, Topon Kumar and Iba, Hitoshi (2004b). Selection of the most useful subset of genes for gene expression-based classification. In Proceedings of the 2004 Congress on Evolutionary Computation (CEC2004), pages 2076–2083, Portland, Oregon, USA.

    Google Scholar 

  • Paul, Topon Kumar and Iba, Hitoshi (2005a). Extraction of informative genes from microarray data. In Proceedings of the Genetic and Evolutionary Computation Conference (GECCO) 2005, pages 453–460, Washington DC, USA. ACM Press.

    Chapter  Google Scholar 

  • Paul, Topon Kumar and Iba, Hitoshi (2005b). Gene selection for classification of cancers using probabilistic model building genetic algorithm. BioSystems, 82(3):208–225.

    Article  Google Scholar 

  • Wang, C., Pattabiraman, N., Zhou, J.N., Fu, M., Sakamaki, T., Albanese, C., Li, Z., Wu, K., Hulit, J., Neumeister, P., Novikoff, P.M., Brownlee, M., Scherer, P.E., Jones, J.G., Whitney, K.D., Donehower, L.A., Harris, E.L., Rohan, T., Johns, D.C., and Pestell, R.G. (2003). Cyclin d1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Molecular and Cellular Biology, 23(17):6159–6173.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Paul, T.K., Iba, H. (2007). Genetic Programming for Classifying Cancer Data and Controlling Humanoid Robots. In: Riolo, R., Soule, T., Worzel, B. (eds) Genetic Programming Theory and Practice IV. Genetic and Evolutionary Computation. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-49650-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-49650-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-33375-5

  • Online ISBN: 978-0-387-49650-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics