- author = "Enrico Buccheri and Daniele Dell'Aquila and Marco Russo",
- title = "Artificial intelligence in health data analysis: The {Darwinian} evolution theory suggests an extremely simple and zero-cost large-scale screening tool for prediabetes and type 2 diabetes",
- journal = "Diabetes Research and Clinical Practice",
- year = "2021",
- volume = "174",
- pages = "108722",
- month = "1 " # apr,
- keywords = "genetic algorithms, genetic programming, BP, Type 2 diabetes, Zero-cost dysglycemia screening, Artificial intelligence",
- ISSN = "0168-8227",
-
URL = "
https://pubmed.ncbi.nlm.nih.gov/33647331/",
-
URL = "https://www.sciencedirect.com/science/article/pii/S0168822721000759",
-
DOI = "
doi:10.1016/j.diabres.2021.108722",
-
abstract = "Aims
The effective identification of individuals with early dysglycemia status is key to reduce the incidence of type 2 diabetes. We develop and validate a novel zero-cost tool that significantly simplifies the screening of undiagnosed dysglycemia.
Methods
We use NHANES cross-sectional data over 10 years (2007 to 2016) to derive an equation that links non-laboratory exposure variables to the possible presence of undetected dysglycemia. For the first time, we adopt a novel artificial intelligence approach based on the Darwinian evolutionary theory to analyze health data. We collected data for 47 variables.
Results
Age and waist circumference are the only variables required to use the model. To identify undetected dysglycemia, we obtain an area under the curve (AUC) of 75.3 percent. Sensitivity and specificity are 0.65 and 0.73 by using the optimal threshold value determined from external validation data.
Conclusions
The use of uniquely two variables allows to obtain a zero-cost screening tool of analogous precision than that of more complex tools widely adopted in the literature. The newly developed tool has clinical use as it significantly simplifies the screening of dysglycemia. Furthermore, we suggest that the definition of an age-related waist circumference cut-off might help to improve existing diabetes risk factors.",
