- author = "Rudi Cilibrasi and Paul Vitanyi",
- title = "A New Quartet Tree Heuristic for Hierarchical Clustering",
- booktitle = "Principled methods of trading exploration and exploitation Workshop",
- year = "2005",
- address = "London",
- month = "6-7 " # jul,
- organisation = "PASCAL",
- keywords = "genetic algorithms, genetic programming, Computational, Information-Theoretic Learning with Statistics, Learning/Statistics, Optimisation, Theory, Algorithms",
-
URL = "
http://www.cwi.nl/~paulv/papers/quartet.pdf",
- size = "22 pages",
- abstract = "We consider the problem of constructing an an optimal-weight tree from the 3Chose(n,4) weighted quartet topologies on n objects, where optimality means that the summed weight of the embedded quartet topologies is optimal (so it can be the case that the optimal tree embeds all quartets as non-optimal topologies). We present a heuristic for reconstructing the optimal-weight tree, and a canonical manner to derive the quartet-topology weights from a given distance matrix. The method repeatedly transforms a bifurcating tree, with all objects involved as leaves, achieving a monotonic approximation to the exact single globally optimal tree. This contrasts to other heuristic search methods from biological phylogeny, like DNAML or quartet puzzling, which, repeatedly, incrementally construct a solution from a random order of objects, and subsequently add agreement values. We do not assume that there exists a true bifurcating supertree that embeds each quartet in the optimal topology, or represents the distance matrix faithfully|not even under the assumption that the weights or distances are corrupted by a measuring process. Our aim is to hierarchically cluster the input data as faithfully as possible, both phylogenetic data and data of completely different types. In our experiments with natural data, like genomic data, texts or music, the global optimum appears to be reached. Our method is capable of handling over 100 objects, possibly up to 1000 objects, while no existing quartet heuristic can computionally approximate the exact optimal solution of a quartet tree of more than about 20-30 objects without running for years. The method is implemented and available as public software.",
-
notes = "http://eprints.pascal-network.org/archive/00001821/
paper improved after workshop?",
