Controle d'un bioreacteur a perfusion pour la regeneration du tissu vasculaire
Created by W.Langdon from
gp-bibliography.bib Revision:1.7650
- @PhdThesis{Couet:thesis,
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author = "Frederic Couet",
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title_en = "Control of a perfusion bioreactor for growth of
vascular tissue",
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title = "Controle d'un bioreacteur a perfusion pour la
regeneration du tissu vasculaire",
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school = "Mines et metallurgi, Laval University",
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year = "2011",
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address = "Quebec, Canada",
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month = oct,
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keywords = "genetic algorithms, genetic programming, biomechanics,
blood, vein",
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URL = "
http://www.theses.ulaval.ca/2011/28452/28452.pdf",
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size = "187 pages",
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resume = "La disponibilit{\'e} limit{\'e}e de vaisseaux sanguins
autologues pour les chirurgies vasculaires telles que
le pontage coronarien ou p{\'e}riph{\'e}rique et les
performances cliniques insuffisantes des proth{\`e}ses
vasculaires pour le remplacement de vaisseaux sanguins
de petit diam{\`e}tre ({\O} < 6 mm) justifie la
recherche dans le domaine du g{\'e}nie tissulaire
vasculaire. L{'}une des strat{\'e}gies explor{\'e}es --
le g{\'e}nie tissulaire fonctionnel -- vise {\`a}
r{\'e}g{\'e}n{\'e}rer un vaisseau sanguin in vitro dans
un environnement contr{\^o}l{\'e} appel{\'e}
bior{\'e}acteur. L{'}objectif de cette th{\`e}se est de
concevoir un bior{\'e}acteur {\`a} perfusion et de
d{\'e}velopper un syst{\`e}me de contr{\^o}le pour ce
bior{\'e}acteur afin d{'}interagir de mani{\`e}re
dynamique avec une construction art{\'e}rielle dans le
but de guider et de stimuler la maturation de
constructions art{\'e}rielles. La principale question
{\'e}tudi{\'e}e dans ce projet est de d{\'e}terminer
comment choisir les conditions de culture {\`a}
l{'}int{\'e}rieur d{'}un bior{\'e}acteur le plus
efficacement possible. Deux grands enjeux ont
{\'e}t{\'e} identifi{\'e}s : d{'}abord, le besoin de
comprendre les diff{\'e}rents ph{\'e}nom{\`e}nes
physiques et biologiques qui se d{\'e}roulent {\`a}
l{'}int{\'e}rieur du bior{\'e}acteur. Ensuite, la
n{\'e}cessit{\'e} de diriger la
r{\'e}g{\'e}n{\'e}ration du tissu vasculaire. Une
commande utilisant le concept de programmation
g{\'e}n{\'e}tique fut d{\'e}velopp{\'e} afin de
mod{\'e}liser en temps r{\'e}el la
r{\'e}g{\'e}n{\'e}ration du tissu vasculaire. En
utilisant les mod{\`e}les g{\'e}n{\'e}r{\'e}s, la
commande recherche une strat{\'e}gie optimale de
culture (d{\'e}formation circonf{\'e}rentielle,
cisaillement longitudinal et fr{\'e}quence du d{\'e}bit
puls{\'e}) en consid{\'e}rant un processus de
d{\'e}cision Markovien r{\'e}solu par programmation
dynamique. Par simulation num{\'e}rique, on montre que
cette m{\'e}thode a le potentiel de favoriser une
croissance plus rapide et plus s{\'e}curitaire des
tissus en culture et permet d{'}identifier plus
efficacement les param{\`e}tres importants pour la
croissance et le remodelage des constructions
art{\'e}rielles. La commande est capable de g{\'e}rer
des mod{\`e}les de croissance non lin{\'e}aires.
Exp{\'e}rimentalement, le syst{\`e}me d{\'e}velopp{\'e}
permet de mieux comprendre l{'}{\'e}volution des
propri{\'e}t{\'e}s m{\'e}caniques d{'}une construction
art{\'e}rielle dans un bior{\'e}acteur.;",
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abstract = "The limited availability of autologous blood vessels
for bypass surgeries (coronary or peripheral) and the
poor patency rate of vascular prosthesis for the
replacement of small diameter vessels ({\O} < 6 mm)
motivate researches in the domain of vascular tissue
engineering. One of the possible strategies named
functional tissue engineering aims to regenerate a
blood vessel in vitro in a controlled environment. The
objective of this thesis is to design a perfusion
bioreactor and develop a control system able to
dynamically interact with a growing blood vessel in
order to guide and stimulate the maturation of the
vascular construct. The principal question addressed in
this work is: How to choose culture conditions in a
bioreactor in the most efficient way? Two main
challenges have been identified: first, the need to
develop a better comprehension of the physical and
biological phenomenon occurring in bioreactors; second,
the need to influence and optimise vascular tissue
maturation. A controller based on the concept of
genetic programming was developed for real-time
modelling of vascular tissue regeneration. Using the
produced models, the controller searches an optimal
culture strategy (circumferential strain, longitudinal
shear stress and frequency of the pulsed pressure
signal) by using a Markov decision process solved by
dynamic programming. Numerical simulations showed that
the method has the potential to improve growth, safety
of the process, and information gathering. The
controller is able to work with common nonlinearities
in tissue growth. Experimental results show that the
controller is able to identify important culture
parameters for the growth and remodelling of tissue
engineered blood vessels. Furthermore, this bioreactor
represents an interesting tool to study the evolution
of the mechanical properties of a vascular construct
during maturation.",
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bibsource = "OAI-PMH server at amican.webapps1.lac-bac.gc.ca",
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contributor = "Diego Mantovani",
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identifier = "TC-QQLA-28452",
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language = "EN",
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language = "FR",
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oai = "oai:collectionscanada.gc.ca:QQLA.2011/28452",
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rights = "{\copyright} Fr{\'e}d{\'e}ric Couet, 2011",
- }
Genetic Programming entries for
Frederic Couet
Citations
