Explanatory Analysis of the Metabolome Using Genetic Programming of Simple, Interpretable Rules

Created by W.Langdon from gp-bibliography.bib Revision:1.7177

@Article{Johnson:2000:eamGPsir,

• author = "Helen E. Johnson and Richard J. Gilbert and Michael K. Winson and Royston Goodacre and Aileen R. Smith and Jem J. Rowland and Michael A. Hall and Douglas B. Kell",
• title = "Explanatory Analysis of the Metabolome Using Genetic Programming of Simple, Interpretable Rules",
• journal = "Genetic Programming and Evolvable Machines",
• year = "2000",
• volume = "1",
• number = "3",
• pages = "243--258",
• month = jul,
• keywords = "genetic algorithms, genetic programming, metabolome, tomato fruit, salinity, Fourier transform infra-spectroscopy (FTIR), chemometrics",
• ISSN = "1389-2576",
• URL = "http://www.biospec.net/pubs/pdfs/Johnson-GPEvolMach2000.pdf",
• DOI = "doi:10.1023/A:1010014314078",
• abstract = "Genetic programming, in conjunction with advanced analytical instruments, is a novel tool for the investigation of complex biological systems at the whole-tissue level.

  In this study, samples from tomato fruit grown hydroponically under both high- and low-salt conditions were analysed using Fourier-transform infrared spectroscopy (FTIR), with the aim of identifying spectral and biochemical features linked to salinity in the growth environment.

  FTIR spectra of whole tissue extracts are not amenable to direct visual analysis, so numerical modelling methods were used to generate models capable of classifying the samples based on their spectral characteristics. Genetic programming (GP) provided models with a better prediction accuracy to the conventional data modelling methods used, whilst being much easier to interpret in terms of the variables used.

  Examination of the GP-derived models showed that there were a small number of spectral regions that were consistently being used. In particular, the spectral region containing absorbances potentially due to a cyanide/nitrile functional group was identified as discriminatory. The explanatory power of the GP models enabled a chemical interpretation of the biochemical differences to be proposed. The combination of FTIR and GP is therefore a powerful and novel analytical tool that, in this study, improves our understanding of the biochemistry of salt tolerance in tomato plants.",

• notes = "Article ID: 264703",

}

Genetic Programming entries for Helen E Johnson Richard J Gilbert Michael K Winson Royston Goodacre Aileen R Smith Jem J Rowland Michael A Hall Douglas B Kell

Citations