Towards Intelligent Biological Control: Controlling Boolean Networks with Boolean Networks
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- @InProceedings{taou2016towards,
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title = "Towards Intelligent Biological Control: Controlling
{Boolean} Networks with {Boolean} Networks",
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author = "Nadia S. Taou and David W. Corne and
Michael A. Lones",
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booktitle = "19th European Conference on Applications of
Evolutionary Computation, EvoApplications 2016, Part
I",
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year = "2016",
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editor = "Giovanni Squillero and Paolo Burelli",
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volume = "9597",
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series = "Lecture Notes in Computer Science",
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pages = "351--362",
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address = "Porto, Portugal",
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month = mar # " 30 -- " # apr # " 1",
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organisation = "EvoStar",
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publisher = "Springer",
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keywords = "genetic algorithms, genetic programming, Gene
regulatory networks, Boolean networks, Control,
Evolutionary algorithms",
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isbn13 = "978-3-319-31204-0",
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DOI = "doi:10.1007/978-3-319-31204-0_23",
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abstract = "Gene regulatory networks (GRNs) are the complex
dynamical systems that orchestrate the activities of
biological cells. In order to design effective
therapeutic interventions for diseases such as cancer,
there is a need to control GRNs in more sophisticated
ways. Computational control methods offer the potential
for discovering such interventions, but the difficulty
of the control problem means that current methods can
only be applied to GRNs that are either very small or
that are topologically restricted. In this paper, we
consider an alternative approach that uses evolutionary
algorithms to design GRNs that can control other GRNs.
This is motivated by previous work showing that
computational models of GRNs can express complex
control behaviours in a relatively compact fashion. As
a first step towards this goal, we consider abstract
Boolean network models of GRNs, demonstrating that
Boolean networks can be evolved to control trajectories
within other Boolean networks. The Boolean approach
also has the advantage of a relatively easy mapping to
synthetic biology implementations, offering a potential
path to in vivo realisation of evolved controllers.",
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notes = "EvoApplications2016 held inconjunction with
EuroGP'2016, EvoCOP2016 and EvoMUSART 2016",
- }
Genetic Programming entries for
Nadia Solime Taou
David W Corne
Michael A Lones
Citations