Genetic programming-based approach to elucidate biochemical interaction networks from data
Created by W.Langdon from
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- @Article{Kandpal:2013:IETsb,
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author = "Manoj Kandpal and Chakravarthy Mynampati Kalyan and
Lakshminarayanan Samavedham",
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journal = "IET Systems Biology",
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title = "Genetic programming-based approach to elucidate
biochemical interaction networks from data",
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year = "2013",
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volume = "7",
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number = "1",
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pages = "18--25",
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keywords = "genetic algorithms, genetic programming",
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abstract = "Biochemical systems are characterised by
cyclic/reversible reciprocal actions, non-linear
interactions and a mixed relationship structures
(linear and non-linear; static and dynamic).
Deciphering the architecture of such systems using
measured data to provide quantitative information
regarding the nature of relationships that exist
between the measured variables is a challenging
proposition. Causality detection is one of the
methodologies that are applied to elucidate biochemical
networks from such data. Autoregressive-based modelling
approach such as Granger causality, partial directed
coherence, directed transfer function and canonical
variate analysis have been applied on different systems
for deciphering such interactions, but with limited
success. In this study, the authors propose a genetic
programming-based causality detection (GPCD)
methodology which blends evolutionary computation-based
procedures along with parameter estimation methods to
derive a mathematical model of the system. Application
of the GPCD methodology on five data sets that
contained the different challenges mentioned above
indicated that GPCD performs better than the other
methods in uncovering the exact structure with less
false positives. On a glycolysis data set, GPCD was
able to fill the 'interaction gaps' which were missed
by other methods.",
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DOI = "doi:10.1049/iet-syb.2012.0011",
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ISSN = "1751-8849",
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notes = "Also known as \cite{6518037}",
- }
Genetic Programming entries for
Manoj Kandpal
Kalyan Mynampati Chakravarthy
Samavedham Lakshminarayanan
Citations