- author = "Richard J. Gilbert and Jem J. Rowland and Douglas B. Kell",
- title = "Genomic computing: explanatory modelling for functional genomics",
- pages = "551--557",
- year = "2000",
- publisher = "Morgan Kaufmann",
- booktitle = "Proceedings of the Genetic and Evolutionary Computation Conference (GECCO-2000)",
- editor = "Darrell Whitley and David Goldberg and Erick Cantu-Paz and Lee Spector and Ian Parmee and Hans-Georg Beyer",
- address = "Las Vegas, Nevada, USA",
- publisher_address = "San Francisco, CA 94104, USA",
- month = "10-12 " # jul,
- keywords = "genetic algorithms, genetic programming",
- ISBN = "1-55860-708-0",
-
URL = "
http://gpbib.cs.ucl.ac.uk/gecco2000/RW045.pdf",
- abstract = "Many newly discovered genes are of unknown function. DNA microarrays are a method for determining the expression levels of all genes in an organism for which a complete genome sequence is available. By comparing the expression changes under different conditions it should be possible to assign functions to these genes. However, many hundreds of thousands of data points may be produced over a series of experiments. Genetic programming provided simple explanatory rules for gene function from such datasets, where previous approaches had not succeeded.",
-
notes = "A joint meeting of the ninth International Conference
on Genetic Algorithms (ICGA-2000) and the fifth Annual
Genetic Programming Conference (GP-2000) Part of
\cite{whitley:2000:GECCO}
DNA chip, microarray mRNA, baker's yeast saccharomyces cerevisiae.
Protected divide by zero =10**15, range protection
6 way classification via 6 classifiers in one individual. Linear GP Five demes (7500 each). 5% migration.
p554 2000 generations. Single point crossover. Conditional branches, loops. Infinite loops trapped.
{"}new insights into biological systems at the genomic level{"}. {"}not been previously reported{"}. Sec 4.
p553 2467 genes x 79??? These missing (data) points were assigned the mean values for the column. log expression. bloat fitness penalty.",
