- author = "Douglas B. Kell",
- title = "Evolutionary algorithms and synthetic biology for directed evolution: commentary on ``on the mapping of genotype to phenotype in evolutionary algorithms'' by Peter A. Whigham, Grant Dick, and James Maclaurin",
- journal = "Genetic Programming and Evolvable Machines",
- year = "2017",
- volume = "18",
- number = "3",
- pages = "373--378",
- month = sep,
- note = "Special Peer Commentary on Mapping of Genotype to Phenotype in Evolutionary Algorithms",
- keywords = "genetic algorithms, genetic programming, Grammatical Evolution, Directed evolution, Synthetic biology, Navigating search spaces, Intelligent operators",
- ISSN = "1389-2576",
-
DOI = "
doi:10.1007/s10710-017-9292-1",
- size = "6 page",
- abstract = "I rehearse two issues around the commentary of Whigham and colleagues. (1) There really are many more reasons than those given as to why natural evolution cannot reasonably find or select the optimal individual. (2) A series of experimental molecular biology programmes, known generically as directed evolution, can use operators and selection schemes that natural evolution cannot. When developed further using the methods of synthetic biology, there are no operators or schemes for in silico evolution that cannot be applied precisely to directed evolution. The issues raised apply only to natural evolution but not to directed evolution.",
-
notes = "Introduction in \cite{Spector:2017:GPEM}
An author's reply to this comment is available at http://dx.doi.org/10.1007/s10710-017-9289-9 \cite{Whigham:2017:GPEM2}.
This comment refers to the article available at: http://dx.doi.org/10.1007/s10710-017-9288-x \cite{Whigham:2017:GPEM}.",
