abstract = "Tight blood glucose control reduces the risk of
microvascular and macrovascular complications in
patients with type 1 diabetes. However, this is very
difficult due to the large intra-individual variability
and other factors that affect glycaemic control. The
main limiting factor to achieve strict control of
glucose levels in patients on intensive insulin therapy
is the risk of severe hypoglycaemia. Therefore,
hypoglycaemia is the main safety problem in the
treatment of type 1 diabetes, negatively affecting the
quality of life of patients suffering from this
disease. Decision support tools based on machine
learning methods have become a viable way to enhance
patient safety by anticipating adverse glycaemic
events. This study proposes the application of four
machine learning algorithms to tackle the problem of
safety in diabetes management: (1) grammatical
evolution for the mid-term continuous prediction of
blood glucose levels, (2) support vector machines to
predict hypoglycaemic events during postprandial
periods, (3) artificial neural networks to predict
hypoglycaemic episodes overnight, and (4) data mining
to profile diabetes management scenarios. The proposal
consists of the combination of prediction and
classification capabilities of the implemented
approaches. The resulting system significantly reduces
the number of episodes of hypoglycaemia, improving
safety and providing patients with greater confidence
in decision-making",
notes = "Universitat de Girona, Spain; Centro de Investigacion
Biomedica en Red de Diabetes y Enfermedades Metabolicas
Asociadas (CIBERDEM),
Spain