Genetic Programming and Neural Networks Feedback Linearization for Modeling and Controlling Complex Pharmacogenomic Systems
Created by W.Langdon from
gp-bibliography.bib Revision:1.8098
- @InProceedings{conf/wilf/Floares05,
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title = "Genetic Programming and Neural Networks Feedback
Linearization for Modeling and Controlling Complex
Pharmacogenomic Systems",
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author = "Alexandru Floares",
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year = "2005",
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editor = "Isabelle Bloch and Alfredo Petrosino and
Andrea Tettamanzi",
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publisher = "Springer",
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series = "Lecture Notes in Computer Science",
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volume = "3849",
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booktitle = "Fuzzy Logic and Applications, 6th International
Workshop, WILF 2005, Revised Selected Papers",
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pages = "178--187",
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address = "Crema, Italy",
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month = sep # " 15-17",
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bibdate = "2006-02-22",
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bibsource = "DBLP,
http://dblp.uni-trier.de/db/conf/wilf/wilf2005.html#Floares05",
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keywords = "genetic algorithms, genetic programming",
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ISBN = "3-540-32529-8",
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DOI = "doi:10.1007/11676935_22",
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abstract = "Modern pharmacology, combining pharmacokinetic,
pharmacodynamic, and pharmacogenomic data, is dealing
with high dimensional, nonlinear, stiff systems.
Mathematical modelling of these systems is very
difficult, but important for understanding them. At
least as important is to adequately control them
through inputs - drugs' dosage regimes. Genetic
programming (GP) and neural networks (NN) are
alternative techniques for these tasks. We use GP to
automatically write the model structure in C++ and
optimise the model's constants. This gives insights
into the subjacent molecular mechanisms. We also show
that NN feedback linearisation (FBL) can adequately
control these systems, with or without a mathematical
model. The drug dosage regimen will determine the
output of the system to track very well a therapeutic
objective. To our knowledge, this is the first time
when a very large class of complex pharmacological
problems are formulated and solved in terms of GP
modeling and NN modeling and control.",
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notes = "Published 2006?",
- }
Genetic Programming entries for
Alexandru Floares
Citations