Analyzing Feature Importance for Metabolomics using Genetic Programming

Created by W.Langdon from gp-bibliography.bib Revision:1.7630

@InProceedings{Hu:2018:EuroGP,

• author = "Ting Hu and Karoliina Oksanen and Weidong Zhang and Edward Randell and Andrew Furey and Guangju Zhai",
• title = "Analyzing Feature Importance for Metabolomics using Genetic Programming",
• booktitle = "EuroGP 2018: Proceedings of the 21st European Conference on Genetic Programming",
• year = "2018",
• month = "4-6 " # apr,
• editor = "Mauro Castelli and Lukas Sekanina and Mengjie Zhang and Stefano Cagnoni and Pablo Garcia-Sanchez",
• series = "LNCS",
• volume = "10781",
• publisher = "Springer Verlag",
• address = "Parma, Italy",
• pages = "68--83",
• organisation = "EvoStar, Species",
• keywords = "genetic algorithms, genetic programming",
• isbn13 = "978-3-319-77552-4",
• DOI = "doi:10.1007/978-3-319-77553-1_5",
• abstract = "The emerging and fast-developing field of metabolomics examines the abundance of small-molecule metabolites in body fluids to study the cellular processes related to how the human body responds to genetic and environmental perturbations. Considering the complexity of metabolism, metabolites and their represented cellular processes can correlate and synergistically contribute to a phenotypic status. Genetic programming (GP) provides advanced analytical instruments for the investigation of multifactorial causes of metabolic diseases. In this article, we analysed a population-based metabolomics dataset on osteoarthritis (OA) and developed a Linear GP (LGP) algorithm to search classification models that can best predict the disease outcome, as well as to identify the most important metabolic markers associated with the disease. The LGP algorithm was able to evolve prediction models with high accuracies especially with a more focused search using a reduced feature set that only includes potentially relevant metabolites. We also identified a set of key metabolic markers that may improve our understanding of the biochemistry and pathogenesis of the disease.",
• notes = "Part of \cite{Castelli:2018:GP} EuroGP'2018 held in conjunction with EvoCOP2018, EvoMusArt2018 and EvoApplications2018",

}

Genetic Programming entries for Ting Hu Karoliina Oksanen Weidong Zhang Edward Randell Andrew Furey Guangju Zhai

Citations