- author = "A. D. Shaw and M. K. Winson and A. M. Woodward and A. C. McGovern and H. M. Davey and N. Kaderbhai and D. Broadhurst and R. J. Gilbert and J. Taylor and E. M. Timmins and R. Goodacre and D. B. Kell and B. K. Alsberg and J. J. Rowland",
- title = "Bioanalysis and Biosensors for Bioprocess Monitoring Rapid Analysis of High-Dimensional Bioprocesses Using Multivariate Spectroscopies and Advanced Chemometrics",
- journal = "Advances in Biochemical Engineering/Biotechnology",
- year = "2000",
- volume = "66",
- pages = "83--113",
- month = jan,
- keywords = "genetic algorithms, genetic programming, Vibrational spectroscopy, Mass spectrometry, Dielectric spectroscopy, Flow Cytometry, Chemometrics",
- publisher = "Springer",
- ISSN = "0724-6145",
- isbn13 = "978-3-540-66052-1",
-
DOI = "
doi:10.1007/3-540-48773-5_3",
- size = "31 pages",
- abstract = "There are an increasing number of instrumental methods for obtaining data from biochemical processes, many of which now provide information on many (indeed many hundreds) of variables simultaneously. The wealth of data that these methods provide, however, is useless without the means to extract the required information. As instruments advance, and the quantity of data produced increases, the fields of bioinformatics and chemometrics have consequently grown greatly in importance. The chemometric methods nowadays available are both powerful and dangerous, and there are many issues to be considered when using statistical analyses on data for which there are numerous measurements (which often exceed the number of samples). It is not difficult to carry out statistical analysis on multivariate data in such a way that the results appear much more impressive than they really are. The authors present some of the methods that we have developed and exploited in Aberystwyth for gathering highly multivariate data from bioprocesses, and some techniques of sound multivariate statistical analyses (and of related methods based on neural and evolutionary computing) which can ensure that the results will stand up to the most rigorous scrutiny.",
-
notes = "Review, Tutorial
PMID: 10592527
variable selection.
p98 {"}PCA does not attempt to relate cause and effect; it merely serves to highlight the larger variations in the data.{"} p106 {"}principle of parsimony{"}...{"}our work has shown the principle holds.{"} p107 {"}Statistical models are not able in general to extrapolate{"}. cites \cite{koza:1995:weston}, DRASTIC papers (3) p108 quote of Gould Organisms{"} influence their own destiny in interesting complex and comprehensible ways{"}",
